Gastroesophageal reflux disease is the reflux of duodenal contents into the esophagus causing heartburn and other symptoms. According to whether it leads to esophageal mucosal erosion and ulceration, it is divided into reflux esophagitis and non-erosive reflux disease. The clinical manifestations of gastroesophageal reflux disease are diverse and vary in severity, and the main manifestations are as follows: 1. Esophageal symptoms: (1) Typical symptoms: Heartburn and reflux are the most common and typical symptoms of the disease. Reflux is the sensation of gastric contents rushing into the pharynx or mouth without nausea and weakness, and is called acid reflux when it contains sour taste or is only acidic water. Heartburn is a burning sensation behind the sternum or under the glabella, often extending upward from the lower end of the sternum. Heartburn or reflux often appears one hour after a meal and can be aggravated by lying down, bending over or increased abdominal pressure. In some patients, heartburn and reflux symptoms can occur at night while falling asleep. (2) Atypical symptoms: chest pain caused by reflux irritating the esophagus and occurring behind the sternum. In severe cases, it can be a severe stabbing pain that radiates to the back, chest, shoulder, neck and behind the ear, sometimes resembling angina pectoris, with or without heartburn and reflux. Some patients may have difficulty swallowing or a foreign body sensation behind the sternum, which is seen in some patients and may be due to esophageal spasm or dysfunction, with intermittent symptoms that can occur with solid or liquid food. 2.Extra-esophageal symptoms are caused by the irritation or injury of tissues or organs other than the esophagus by refluxed material, such as pharyngitis, chronic cough and asthma. In some patients with the above-mentioned diseases of unknown etiology and prolonged treatment, it is important to pay attention to the presence of gastroesophageal reflux with heartburn and reflux symptoms that are suggestive. A few patients have pharyngitis, chronic cough or asthma as the first or main manifestation. In severe cases, aspiration pneumonia and even interstitial lung fibrosis may occur. 3. Complications: Complications such as upper gastrointestinal bleeding, canal stenosis and Barrett’s esophagus can occur. Therefore, according to the severity of symptoms in a timely manner, choose to seek medical consultation to avoid delaying the disease.