Tertiary cytopenia is generally serious, but its severity is closely related to the cause of the tertiary reduction, the degree of reduction, and the quality of the individual. Tertiary cytopenia is a total reduction of white blood cells, red blood cells, and platelets in the blood. Tertiary cytopenia can be seen in hematologic diseases, such as leukemia, aplastic anemia, myelodysplastic syndromes, etc. It can also be seen in non-hematologic diseases, such as systemic lupus erythematosus, liver diseases, severe infections and hypersplenism. 1. Hematologic diseases: such as leukemia, aplastic anemia, myelodysplastic syndromes and so on. Most of the mild aplastic anemia can be relieved after active treatment, and the condition can generally be controlled. However, severe aplastic anemia is generally more severe and has a high early mortality rate. Leukemia and myelodysplastic syndrome are malignant hematologic diseases, which are very serious. 2. Non-hematologic diseases: including hypersplenism, rheumatologic immune diseases, severe infections, liver diseases, etc., which are not as serious as the malignant hematologic diseases, but also need to receive timely treatment for the cause of the disease, such as systemic lupus erythematosus, which needs to be treated with prednisone and other medications in order to improve the prognosis. In the case of trilineage cytopenia, it is recommended to undergo other relevant examinations to clarify the cause of the disease and standardize the treatment under the guidance of the doctor in order to avoid delaying the condition.