Creatinine 265μmol/L is usually abnormal and is mildly elevated. It may be caused by physiological reasons such as higher muscle content or eating more meat in general, or it may be caused by pathological reasons such as acute kidney injury or chronic renal insufficiency. Normal serum creatinine ranges from 53 to 106 μmol/L in men and from 44 to 97 μmol/L in women. Therefore, creatinine 265 μmol/L is not normal and is mildly elevated. Some patients with elevated creatinine may be caused by their own high muscle content, or eating more meat and exercising more in general. If there is no abnormality in urine routine and urinary system ultrasound and other related examinations, creatinine may return to normal after adjusting the lifestyle, and there is no need for special treatment at this time. If patients have acute kidney injury with elevated creatinine due to various reasons, creatinine may return to normal after correcting the reversible causes; if chronic renal insufficiency leads to elevated creatinine, which is usually irreversible, it is necessary to actively treat the primary disease and delay the progressive deterioration of renal function, and creatinine usually cannot return to normal. If patients find that the creatinine is elevated, it is recommended to go to regular hospitals in time, improve the examination to clarify the cause of the disease, and then give targeted treatment or therapy under the guidance of the doctor.