High type IV collagen is considered to be related to liver diseases, such as liver fibrosis or cirrhosis, etc. A simple high index is not a direct confirmation of the diagnosis. Type IV collagen is one of the main indicators of liver fibrosis, which can reflect the presence of liver fibrosis more sensitively. If liver fibrosis is present, type IV collagen will be high. Liver fibrosis is easily triggered when hepatitis or fatty liver occurs. If high collagen type IV is evident, an association with cirrhosis cannot be ruled out. When cirrhosis occurs, it will affect liver function and cause irreversible pathological changes in the liver, requiring active treatment. When abnormal liver lesions are found, timely treatment is needed, regular review, and timely adjustment of the treatment program according to the recovery situation and changes in the condition to prevent aggravation of the condition. In daily life, pay attention to quit smoking and drinking, and eat less overly greasy food. Maintain a good mindset and regular living habits to avoid increasing the burden on the liver, otherwise it is not conducive to the recovery of the condition.