The TCM diagnosis of periappendiceal abscess is “intestinal carbuncle”, which should belong to the category of intestinal carbuncle and pus. The classic formula for treating intestinal canker in the Jin Kui essentials is Rhubarb Mudan Tang and Coix seeds and sorghum. The Jin Kui essentials says: “…… body without heat, pulse count, this is intestinal canker and pus, Coix seeds and sorghum are the main ingredients.” “…… pus has not yet become, can be lowered, when there is blood. The pulse is flooded, the pus has become, can not be down. The rhubarb peony soup is the main one.” Although the Jin Kui Yao suggests the use of Coix Seed and Fructus Defeat Soup for formed pus and Da Huang Mudan Tang for unformed pus, from the experience of Jing Fang master Cao Yingfu in treating intestinal carbuncle and his clinical practice over the years, whether the pus is formed or unformed, the use of Da Huang to attack and detoxify the internal organs and make the evil poison come out from the stool is a shortcut to treat intestinal carbuncle, and the effect is obviously diminished if Da Huang is not used to pass down the pus. Therefore, in my clinical practice, I often use Rhubarb Mudan Tang combined with Semen Coicis Fructus Fructus as the basic formula for treating appendiceal abscess. Studies have shown that rhubarb can protect the intestinal mucosal barrier, improve intestinal microcirculation, promote intestinal peristalsis, inhibit bacterial translocation in the intestine, remove toxic substances in the intestine, and prevent and reduce the occurrence of endotoxemia. Mannitol can laxative and laxative, moisten dryness and soften hardness, clear fire and reduce swelling, and can be used with rhubarb to strengthen the function of internal organs. Mudanpi, Paeonia lactiflora and peach kernel cool the blood and detoxify it, while Chai Hu and Citrus aurantium dredge the liver and move the qi, which can promote the dissipation of abscesses. It is also important to use raw Coix Seed to relieve dampness and subdue swelling, and to use Sulforaphane to drain pus and break blood and detoxify the blood, while Red Vine is an important medicine for treating intestinal canker, which can clear heat and detoxify the blood and relieve pain. The effect of the lesser herbs is threefold: (1) to help the coix seeds to resolve dampness; (2) to invigorate yang energy; (3) the herbs are good at walking and can be used in the flexure of the intestines. The “Justice of the Materia Medica” says that “the seeds are good at walking, so they are the pure Yang medicine that passes through the twelve channels.” Pharmacological studies have shown that Coix seeds, sophora, and fenugreek all have good anti-inflammatory effects. The addition of raw Astragalus can benefit qi and drain pus; the addition of soapberry and trigon can invigorate blood circulation and resolve blood stasis, dissipate nodules and promote abscess absorption. The dosage of Radix Aconiti in the formula is small and it is combined with a large number of heat-clearing and detoxifying drugs, so no adverse reactions have been seen in clinical applications, regardless of whether there is fever or not. Modern experimental research has confirmed that Ruyi Jinhuang San not only has antibacterial and anti-inflammatory effects, but also activates macrophages and increases their phagocytic ability, which has the effect of improving the immune ability of the body. The combination of internal Chinese medicine and topical application of Ruyi Jinhuang San further enhances the curative effect on periappendiceal abscess. If the patient’s abdominal pain worsens, the abdominal mass increases and the peritonitis expands during the treatment, the patient is considered to be ineffective in conservative treatment and is referred to surgery. The treatment of peri-appendiceal abscess with the Chinese medicine “Dahuang Mudan Tang combined with Coix Seeds and Fructus Abscess as an addition” together with antibiotics can effectively promote the absorption of peri-appendiceal abscess and relieve abdominal pain, and the efficacy is significantly better than that of using antibiotics alone, which is worthy of clinical promotion.