Pancreatic cancer fever at night may be related to the thermogenic source released by cancer cells themselves or secondary bile duct infection, and the cause should be clarified in time to take causative treatment. If the fever is caused by the toxin produced by the growth and reproduction of cancer cells, physical cooling can be used, such as rubbing the body with 50% ethanol or placing ice cubes or ice packs on the forehead and armpits; medicines can also be used to reduce the fever, such as using anti-inflammatory pain suppository to reduce the fever by anus plug, or taking ibuprofen to reduce the fever by mouth, and so on, and the use of medicines should comply with the doctor’s instruction. If it is caused by secondary bile duct infection, it is due to the decrease of cancer patients’ own immunity or the application of adrenocorticotropic hormone to aggravate the low immunity and the invasion of intestinal bacteria into the bile duct causing secondary infectious fever. Generally, the third-generation cephalosporins are often used with better effect, and carbapenem penicillins can also be applied when necessary, and antibacterial drugs can also be selected through bacterial culture and drug sensitivity test. Pancreatic cancer symptoms of fever at night, should be timely consultation, so as not to delay the condition.