The most common manifestation of appendicitis is abdominal pain, which is commonly known as stomach pain. The typical symptom is pain in the upper abdomen at the beginning, a pain in the stomach area, giving the impression that it occurs as a result of acute gastroenteritis or after eating an unclean diet. It is a manifestation of inaccurate localization of the nerves in the gastrointestinal tract. After a few hours, the pain gradually shifts and becomes fixed in the right lower abdomen. In particular, the pain is more pronounced and progressively worse at the intersection of the umbilicus and the external and external 1/3 of the right anterior superior iliac spine, the surface projection of the appendix. Initially, the pain is stabbing, and gradually it becomes knife-like, involving the mural peritoneum and presenting as a limited peritonitis. The pain progressively increases because the mural peritoneum is an innervated area with precise and sensitive nociceptive localization.