In general, close cooperation between patients and physicians is the key to treatment. Generally speaking, the following types of patients are very difficult to treat: 1. Full of misconceptions, they have more ideas than doctors, so treatment often fails to adhere to, and cannot execute medical advice well. 2.Listening to too much advertising and accepting a lot of wrong propaganda, so the treatment follows the advertisement 3.Disobeying the doctor and avoiding medicine, worrying too much about the side effects of medicine, so they cannot stick to a longer course of acne treatment. 4. Excessive involvement in the etiology and pathogenesis of acne, overemphasizing certain causes in the body, such as endocrine, and thus demanding a “cure”, not understanding or trusting the treatment plan and ideas of the physician, and unable to cooperate with the physician’s treatment. 5.The belief that cosmetics have no side effects and are effective, so often seek cosmetics for treatment, and believe in the “conditioning” of beauty salons rather than seeking regular hospital medical treatment. The last thing to emphasize is that if you can cooperate with your doctor and achieve better communication between the doctor and the patient, even the most stubborn and severe acne can be treated very satisfactorily. Of course, it is undeniable that many doctors and hospitals nowadays do not pay much attention to the treatment of this minor problem, and the lack of experience of some doctors, even dermatologists, in the treatment of this disease is one of the major reasons why patients are disappointed with their doctors’ treatment.