Cholinergic urticaria must be treated for its cause if it is to be cured. It is currently believed that cholinergic urticaria is a kind of heat and resistance urticaria without a clear source of infection, mainly due to emotional excitement and induced urticaria. The treatment of cholinergic urticaria should be done by avoiding triggering factors, avoiding sports, contact with hot water, and emotions should not be provoked. In addition, second-generation antihistamines can be applied appropriately, and some herbal medicines can also be combined with appropriate treatment. For cholinergic urticaria, if the symptoms are severe, topical medications can be used in combination, mainly to stop itching and symptomatic treatment, such as glycolic lotion, have a better effect.