If you have a burning sensation at the urethra when you urinate, you should first consider inflammation of the urethra, such as the urethra being infected with bacteria, mycoplasma, chlamydia, mycobacteria, trichomonas and other infections that cause the urethra to become congested and edematous. When the urine stream passes through the urethra, the edematous mucosa is irritated, causing a burning sensation. In this case, it is advisable to go to the hospital to take the urethral discharge for examination to clarify the specific causative organism causing the urethritis, and then carry out targeted treatment. If it is caused by bacterial infection, you can take oral quinolone antibiotics, such as levofloxacin tablets or cephalosporins; if it is caused by mycoplasma chlamydia infection, it is recommended to take oral azithromycin, memantin and other treatments; if it is caused by trichomonas infection, it is recommended to take oral metronidazole for treatment.