After 10 years of continuous consumption of eszopiclone tablets may develop resistance to the drug, resulting in failure to achieve the therapeutic effect of taking it. Dependence may also develop so that the organism needs to rely on the drug to be able to sleep. Eszopiclum tablets belong to a benzodiazepine sedative hypnotic drugs, the drug can help patients with insomnia to improve the quality of sleep, so it is commonly used in the treatment of insomnia caused by various reasons. Drugs taken for a long time, easy to produce drug resistance, so to a certain extent will affect the therapeutic effect of the drug. When taking eszopiclone tablets produce drug-resistant reaction, in terms of treatment, need to increase the appropriate dose of drugs, or need to combine with other sedative hypnotic drug treatment. Prolonged use of the drug is also prone to dependence, so that the patient must rely on the phenomenon of the drug to be able to sleep, and after the withdrawal of the drug will appear obvious withdrawal reaction. Due to the different physical condition of the individual, the use of different methods of medication, so the symptoms may also have some differences, the specific situation can ask the doctor to analyze in conjunction with the actual situation.