Drug ion introduction therapy is the use of Chinese medicine in the kidney acupuncture point by ultrasonic ion introduction, with the help of local acupoint stimulation, drug penetration, so as to achieve the effect of improving kidney blood flow, reducing proteinuria, hematuria and improving kidney function. Therapeutic mechanism: The active ingredients of Chinese medicine enter the body through the openings of sweat ducts, pores, skin gland openings and cell gaps on the skin. When the skin is energized, the voltage is mainly generated on both sides of the keratin, which can cause the redistribution of aC helical keratin peptide molecules in the keratin layer and the formation of new pore structures, which is conducive to the passage of electric current and makes the drug easy to penetrate. And blood flow electricity itself produces a series of complex electrophysiological or biological changes, combined with drug ions into the body to produce the pharmacological effect, there is a coordinated role in the treatment process. Through drug ion introduction treatment can improve the hemodynamics of the patient’s residual renal unit, inhibit the progression of glomerulosclerosis and interstitial fibrosis, protect the residual renal unit, thus reducing proteinuria and hematuria in patients with chronic nephritis and delaying the progression of renal failure in patients with early chronic renal failure. Treatment method: According to the pathology and pathogenesis of chronic kidney disease, Chinese medicine dialectical typing formulas are formulated and intensively decocted. Treatment with ultrasonic ion introduction instrument. Chronic kidney disease has a long course, the efficacy is not ideal, there is no special treatment method, many patients progress to uremia need to rely on dialysis or kidney replacement, bringing great psychological burden and economic burden for patients. Drug ionization therapy as part of the comprehensive treatment of chronic kidney disease, can improve the efficacy, and safe, non-invasive, easy to operate, without any side effects, can effectively slow down the progress of the disease to uremia. It has good social benefits.