to cause significant morphological changes in cultured fibroblasts in vitro, inhibit nuclear division and proliferation of cells, and induce apoptosis of fibroblasts. Chuanxiong Ligusticum activates blood circulation and resolves blood stasis, and also has the effect of moving Qi. Modern pharmacological studies have shown that the active ingredient of Chuanxiong Ligusticum can inhibit platelet activation and aggregation and release reactions, blocking or reducing the chronic kidney damage initiated by them. Chuan I rhizome (Chuanxiong zin) can improve blood 6 a ketone a prostaglandin Fla content, correct the imbalance of prostacyclin/8 bolus A2 balance, improve blood flow and hypercoagulability, increase renal blood flow, improve creatinine clearance, reduce urea nitrogen, and restore renal function Li6.iv]. Recent studies have found that the level of endothelin (ET) in the blood of patients with chronic renal failure is significantly increased, and El” can significantly reduce renal blood flow and glomerular filtration rate, and also lead to contraction of thylakoid cells and decrease in glomerular capillary ultrafiltration coefficient, and clinical observation that Chuanxiongzin can reduce El”, thus improving the renal function status in chronic renal failure. Astragalus functions to replenish Qi and raise Yang, benefit Qi and fix the surface, promote water retention and swelling, and support sores and muscles, and is a commonly used clinical medicine to benefit Qi and strengthen the spleen. Modern pharmacological studies have concluded that Astragalus can enhance the immune function of the body, and at the same time has a significant diuretic and reduce urinary protein effect on experimental nephritis animals. It was clinically found that CD3, CD4, CD4/C ratio and serum immunoglobulin were lower than normal in patients with chronic renal failure, and the application of Astragalus injection could significantly increase the above indexes and improve the immunity of patients. Astragalus can also improve kidney function. Xianling spleen is a tonic of Chinese medicine, and studies have found that it has the ability to improve lipid metabolism, reduce the distribution of extracellular matrix in the kidney, dilate blood vessels, lower blood pressure, reduce the intra-glomerular pressure of residual glomeruli, and reduce the harmful effects of hyperperfusion hyperfiltration. Compounding research Compounding treatment is the advantage of TCM, which can improve the efficacy of Chinese medicine, while taking into account the symptoms and the root cause, and can better reflect the overall understanding of Chinese medicine on chronic renal failure, and has achieved promising results in clinical application. The total effective rate of the formula was 81.41% in the clinical treatment of blood stasis chronic renal failure, which was different from that of the control group with the application of packaged aldehyde oxidized starch. This formula not only reduced serum urea nitrogen and creatinine levels, but also for the fibrosis indexes serum laminin (LN), fibronectin (FN), precollagen type III (PC I III), and collagen type IV (C I IV), it was able to reduce LN, PC I III, C-IV and elevate FN, indicating that this formula was used to delay the process of chronic renal failure by improving renal fibrosis [18′ . Animal experiments also found that this formula can reduce vascular endothelin (ET) and angiotensin I and II (AT-I, AT-I II), resulting in a significant reduction in glomerular atrophy and a significant reduction in interstitial connective tissue hyperplasia. Fu Zheng and Lowering Turbidity Tang: This formula consists of Dang Shen, Huang Qi, Da Huang, Dan Shen, Angelica, Epimedium, Chen Pi, Semen, Fructus Lycii, Poria as the basic formula, Wang Jinxue et al [24′ through long-term observation of 3-57 months, the slope of linear regression b of 1/Scr and treatment course (month) after treatment was greater than before treatment, and the Scr was significantly lower than before treatment at 3 months and 6 months after treatment, and the Ccr had a rising trend after treatment, and at 3 months There was a significant increase at 3 months. The risk of entering ESRF at 3 years after treatment was reduced by 46.15%. Renal failure punch: This formula consists of Dang Shen, Dan Shen, Huang Lian, Radix et Rhizoma, and Radix et Rhizoma. He Liqun et al_2J applied this formula to animals with chronic renal failure induced by 5/6 nephrectomy could significantly improve renal tissue structure, increase the number of glomeruli, improve renal tubular function, and delay the progression of renal failure. Renkangling: Ginseng, Astragalus, Fructus Lycii and Epimedium are used as monarchs, Salviae, Yimoucao and Rhubarb are used as ministers, and Shiwei and Plantago are used as adjuvants. The total clinical efficiency is 85.3%, which can significantly improve erythrocyte b receptor ring (RBC- C3bI) and RFER, reduce erythrocyte immune complex ring (RBC- ICR) and improve erythrocyte immune function. This formula is composed of Astragalus membranaceus, Radix et Rhizoma Polygonati, Salviae Miltiorrhizae and Rhizoma Polygonati. In animal experiments, Hu Haixiang et al_2 ] found that this formula can affect renal tissue transforming factor 6 (TGF-) in kidney tissue and inhibit the expression of TGF-B mRNA in rats with chronic renal failure. The formula consists of Astragalus membranaceus, Radix et Rhizoma Polygonati, Atractylodes Macrocephala, Poria, Mucuna pruriens, Chuan Hou Pu, Fructus Lycii, Radix et Rhizoma Dioscoreae, Radix et Rhizoma Niubizi, Radix et Rhizoma Yixi, Radix et Rhizoma Salviae Miltiorrhizae, etc. In the experiment of Liu Yi et al._28J, it was found that this formula could correct the low calcium and high phosphorus status in chronic renal failure by reducing urinary calcium, increasing urinary phosphorus, increasing blood parathyroid hormone (whetstone) and decreasing calcitonin (ET). Bao Yuan Jian Ren Capsules: This formula is based on Cordyceps sinensis, Rhubarb, Angelica sinensis, Red ginseng, Salviae sinensis, and He Shou Wu. Zhao Hua et al [29] found through clinical observation that Bao Yuan Jian Ren Capsules improved BUN, Scr, and Ccr while reducing urinary retinol binding protein (RBP) a microglobulin, and N-acetylaminoglucosidase (NAG), thus improving renal tubular function. Research on treatment method Currently, in addition to the conventional application of Western medicine for symptomatic treatment and Chinese medicine for evidence-based treatment, there are some special therapies to make up for the lack of treatment of renal failure: retention enema method: retention enema is one of the main methods of Chinese medicine for the treatment of chronic renal failure. The classical enema formula is 30 g each of rhubarb, forged oyster and dandelion, add 600-800 ml of warm water, decoct about 150-200 ml, and retain the enema for more than 30 min. Generally with the clearing of heat and detoxification, blood circulation and blood stasis, the flow of qi to guide the stagnation of Chinese medicine, such as clearing heat and detoxification of Chinese herbs such as honeysuckle, forsythia, June snow, Tu Fu Ling, ground elm, half a lotus, gardenia, etc.; blood circulation and blood stasis of Chinese herbs such as salvia, motherwort, peach kernel, safflower, Mao Dongqing, etc.; the flow of qi to guide the stagnation of Chinese herbs such as Mu Xiang, heliotrope, etc. Chinese medicine foot bath sweating method: Zhu Xiaoli’ choose Sichuan pepper, safflower, atractylodes, pseudostellaria, wind, qiangwu, douhu, ephedra, gui zhi, mugwort each 25 g, add water boiling 15minD| into the water handle, to be warm when the feet immersed in it, and then gradually heat the water (the temperature to the feet can tolerate shall prevail), a total of 30-40 min, soak the circumference of sweating, once a day, 30 times for a course of treatment.