Cephalosporin is a general term for cephalosporin antibacterial drugs, and there is a high chance that drinking alcohol while taking cephalosporin antibacterial drugs will cause a disulfiram reaction, and the exact odds are often difficult to count. Once patients take cephalosporin antibacterial drugs during drinking, there is a high probability of disulfiram-like reaction, causing dizziness, hallucinations, drowsiness, nausea, vomiting, headache, and generalized flushing and other symptoms, and may even cause a drop in blood pressure, and even shock, the patient’s life and health will pose a threat, so during the use of the drug as well as one week after the discontinuation of the drug should not be drinking alcohol. Cephalosporins as a kind of antibiotics, in the process of using also have certain adverse reactions, including nausea, diarrhea, bloating, indigestion and loss of appetite, etc., in the case of drinking alcohol at the same time, it will exacerbate the adverse reactions of the drug, thus causing different degrees of damage to the body. In order to ensure the safety of the medication, patients should always get the guidance of a specialist.