High eosinophils that do not go down after taking allergy medication may be due to repeated exposure to disease-causing factors, resistance to medication, and the severity of the disease. 1. Repeated exposure to disease-causing factors: Eosinophilia may be caused by long-term exposure to allergens, such as pollen and mites. If you take medication and do not stay away from the causative factor, but also repeated exposure, it will lead to eosinophils do not decline. Patients who do not know the type of allergens need to check the allergens as soon as possible and then stay away. 2. Drug resistance: There are many types of anti-allergy drugs, such as chlorpheniramine and cyproheptadine. If you need to take it for a long time, it may cause drug resistance, so even if you use the drug, the symptoms may not get better, and the eosinophils can’t go down. At present, you can follow the doctor’s advice to replace other anti-allergy drugs, such as phenylephrine, cetirizine and so on. 3. Serious condition: the seriousness of the disease leads to increased eosinophils, oral anti-allergy drugs can not be reduced, this kind of patients can be intravenous or subcutaneous intramuscular injection of anti-allergy drugs to achieve the therapeutic purpose. Eosinophilic hyperplasia may appear skin rash, itching and other symptoms, found similar abnormalities should be timely consultation, and combined with the doctor’s advice on symptomatic treatment.