Taking oral HIV blocking drugs does not affect the window period. The window period generally refers to the period of time between infection with an infectious disease and the time when the disease can be detected, because pathogens such as bacteria and viruses need time to replicate and proliferate after entering the human body before they can be detected. The window period for HIV is generally 14 to 21 days, and the Diagnostic Criteria for AIDS and HIV Infection 2019 Edition indicates that the window period during which HIV antibodies, antigens, and nucleic acids can be detected by existing technology is about 21, 14, and 7 days, respectively. Although viral antibodies cannot be detected during the window period, the HIV virus is already present in the infected person’s body, so the infected person in the window period is equally infectious. There are no studies showing that HIV blocking drugs affect the window period. Blocking drugs block the viral replication process by inhibiting the reverse transcriptase enzyme and do not affect the antibodies produced by the body, so they do not affect the window period. Patients suspected of being infected with HIV are advised to go to the hospital in a timely manner and follow the guidance of a medical professional.