Some patients with multiple myeloma develop recurrent lung infections, urinary tract infections, skin infections and herpes zoster early or during the course of the disease, and they are more difficult to treat than normal. Studies from Sweden have reported that more than one in five patients with multiple myeloma die from infections within one year of diagnosis. To be exact, 22% of patients with multiple myeloma died from infection-related causes within one year of diagnosis. Overall, patients with multiple myeloma had a seven-fold higher risk of infection than those in the drug-controlled control group. In the first year after diagnosis, this risk is almost 12 times higher. Why are patients with multiple myeloma susceptible to co-infection? There are several main reasons: Humoral immune deficiency: Patients with myeloma have a decreased immunity due to elevated amounts of abnormal immunoglobulins leading to decreased normal immunoglobulins. Longer hospitalization: The environment of the ward has a lot of bacteria, and if the hospitalization is too long, many bacteria that are not pathogenic to normal people (conditional pathogens) can become pathogenic at this time with reduced immunity, leading to the occurrence of infection. Neutropenia: Neutropenia can be caused by the disease itself or by chemotherapy, and the longer the neutropenia lasts, the higher the probability of infection. Chemotherapy: Basically all chemotherapy drugs can cause a decrease in immunity and increase the risk of infection. Long-term application of hormones: For the treatment of myeloma, glucocorticoids are very important drugs, and almost all regimens contain glucocorticoids. The long-term application of hormones increases the risk of infection significantly. In addition, patients with myeloma often have pathological fractures, are bedridden for a long time, and are prone to skin infections, or crushing pneumonia, etc. Therefore, it is recommended that patients with multiple myeloma can be vaccinated and encouraged to perform activities that prevent infections from occurring. If signs of infection such as fever appear, promptly visit the hospital for timely treatment.