Calcification of thyroid cysts refers to the occurrence of foci of calcification in thyroid cysts as described on ultrasound. Typically, thyroid cysts are round, have clear borders, and show regular internal echoes on ultrasound, presenting as areas of no echogenicity. Thyroid cysts present with calcification following calcium salt deposition, at which point the nature of the calcification is assessed. If there is sediment granular calcification with irregular internal echoes, unclear borders, and an aspect ratio greater than 1, consider the possibility of malignancy. Under normal circumstances, the majority of thyroid cysts are benign tumors, and in rare cases, signs of malignancy may occur. If a thyroid cyst increases rapidly in a short period of time or shows signs of malignancy, surgical resection is required, and the diagnosis is further confirmed based on the results of surgical resection. For calcification of thyroid cysts, it is recommended to consult the department of thyroid and breast surgery or endocrinology in regular hospitals.