Toothache medication does not get better because of pulpitis, apical periodontitis, no root canal treatment, simply take medicine can not cure the symptoms of toothache. 1. Pulpitis is mainly caused by dental caries, periodontal disease or dental trauma to the nerve of the tooth by infection and damage. When pulpitis occurs, it is necessary to seek medical treatment in time for root canal treatment, through drugs or mechanical methods to make the nerve lose biological activity and clean up, so as to completely stop the pain, the further development of pulpitis will lead to periapical inflammation, the same need to carry out root canal treatment. 2. And take drugs such as anti-inflammatory drugs (such as amoxicillin, metronidazole, tinidazole) or painkillers (such as ibuprofen) can only temporarily relieve the symptoms, and can not be taken for a long period of time, only a root canal can be fast and effective pain relief. It is recommended to consult a doctor in time to identify the cause of the disease for targeted treatment, the use of drugs need to follow the doctor’s instructions.