Pre-eclampsia may have female or male causes, or may be caused by external factors, and cannot be generalized. Common causes include sperm chromosome abnormality, female genital abnormality, endocrine abnormality, and embryo chromosome abnormality. 1. Sperm chromosome abnormality: Sperm chromosome abnormality in men leads to chromosome abnormality in embryos, which may cause preeclampsia. 2. Female genital anomalies: when a woman has uterine abnormalities, such as uterine dysplasia, double uterus, mediastinal uterus, etc., uterine fibroids, uterine adenomyosis, uterine adhesions, etc., they may affect the embryo’s implantation and development, thus leading to preeclampsia. 3. Endocrine abnormalities: when women have luteal insufficiency, hyperprolactinemia, polycystic ovary syndrome, hypothyroidism, diabetes mellitus, poor glycemic control and other endocrine abnormalities, it may also lead to preeclampsia. 4. Embryonic chromosome abnormality: influenced by external factors, when the embryo or fetus chromosome abnormalities in number and structure, it may also trigger the occurrence of preeclampsia. It is recommended that women with preeclampsia should take bed rest, actively seek medical treatment for fertility preservation, avoid sexual intercourse during the period of fertility preservation, and avoid any external stimuli.