Cranial repair is a routine procedure in neurosurgery. In recent years, the number of cases of cranial defects due to various reasons has increased, and cranial repair is more widely performed in clinical practice. In the long-term development practice, the surgical technique has been improved continuously, and the cranial repair materials have been evolving, becoming more and more advanced, mature and ideal. For example, polyether ether ketone (PEEK), which is gradually being promoted in clinical practice, is an ideal replacement material for artificial skull bone with excellent performance and good clinical results. Here is a case of polyetheretherketone artificial skull peek repair. Ms. Wang from Shanxi suffered serious craniocerebral trauma in a car accident and underwent craniotomy and decompression by local hospital, leaving a large cranial defect on the left frontal-temporal top and a serious collapse of the scalp, which affects the aesthetic appearance and also produces some dizziness and headache, unfavorable limbs and other cranial defect syndromes. Therefore, Ms. Wang urgently needs to undergo cranial repair as soon as possible. But what material to choose for repair is a big problem in front of Queen Wang and her family. Many hospitals only have titanium mesh material, but they learned that titanium mesh has many defects and shortcomings, so they want to find a more advanced material. They learned through various means that there is a polyetheretherketone PEEK material with better performance and more ideal repair results, and they came all the way to Beijing to seek medical treatment. After we received Ms. Wang’s diagnosis and evaluation, we made a personalized 3-D shaped PEEK plate for her, and then successfully performed PEEK cranioplasty, restoring her skull to an aesthetically pleasing shape and rebuilding her self-confidence, and her physical activity and mental state were greatly improved after surgery, with excellent results. Therefore, PEEK is a very good material for cranial repair. Its properties, including hardness, thermal insulation, elasticity, and histocompatibility, are very close to human autologous cranial bone, and there is no adverse reaction after placement in the human body, and the precise shaping through three-dimensional reconstruction highly restores the cranial structure, and the appearance is almost the same as before the cranial defect. Our team is using this advanced new polyether ether ketone PEEK material extensively, constantly innovating technology, and introducing the concept of aesthetic plastic surgery, while carrying out comprehensive PEEK cranial repair plastic surgery, which can achieve anatomical integrity, functional perfection, and aesthetic appearance of good results, which is well received and recognized by the majority of patients.