The typical symptoms of acute biliary colic are mainly: 1. pain in the right upper abdomen or pain in the stomach area; 2. pain usually peaks in about 1 hour, lasts about 30 minutes, and usually relieves within 6 hours and is accompanied by nausea, vomiting, and profuse sweating. The first choice of ancillary tests for gallbladder disease is mainly abdominal ultrasound, which can diagnose the presence of gallbladder stones very quickly, easily and non-invasively. Common comorbidities of gallbladder stones are cholecystitis, common bile duct obstruction, common bile duct stones, and biliary pancreatitis due to gallstones. Patients with gallbladder stones that present with comorbidities require surgery because after one comorbidity, the chances of having another comorbidity will be 30% per year and more severe than the previous one. The vast majority of asymptomatic gallstones and cholelithiasis do not require surgery, and only 1% of people will develop symptoms each year, and more than 80% of patients will not have symptoms. Even if the other 20% begin to develop symptoms in the next 10-15 years, the likelihood of comorbidities is unlikely. The preferred surgical procedure for cholecystectomy is trans-laparoscopic cholecystectomy.