Itchy and painful vaginal opening is best treated in time, and can be treated in the following ways: First, itchy and painful vaginal opening may be caused by gynecological inflammation, such as vaginitis and pelvic inflammatory disease. Secondly, you can use vulva cleanser to cleanse, such as Jelqing, Gynecare, and potassium permanganate to cleanse, which can effectively relieve the symptoms of the disease. Third, physical therapy, such as nebulization therapy and microwave therapy, can effectively relieve the itchy and painful vaginal opening.