The following can cause pain and itching at the vaginal opening: 1. Inadequate estrogen levels, due to premature ovarian failure or decline in ovarian secretion after menopause, the level of secreted estrogen decreases, resulting in pain and itching at the vaginal orifice due to atrophy and cracking. 2. Frictional damage, forced entry or excessive frictional stimulation during sexual intercourse can damage the mucous membrane at the vaginal opening and cause pain, followed by pathogenic microbial infections causing itching. 3. 3. scabies mite infection in the vulva, scabies infection in the vulva can cause itching in the vaginal opening. 4. vaginitis, various types of pathogenic microbial infections cause vaginitis, inflammatory secretions flow out to stimulate the vaginal opening, resulting in inflammatory reaction in the vaginal opening causing local pain and itching, often accompanied by Abnormal discharge and odor.