1, Any part of the body, such as the breast, skin, lips and tongue or other parts of the body have hard palpable nodes or lumps that do not disappear. 2.Warts or moles with changes such as deepening color, rapid increase in size, itching and hair loss, ulceration or bleeding. 3.Persistent indigestion. 4.Swallowing of coarse and hard objects with a feeling of choking, discomfort behind the sternum, burning pain or foreign body sensation in the esophagus. 5.Tinnitus, hard of hearing, nasal congestion, headache, blood in the throat discharge, neck lump. 6.Persistent hoarseness, dry cough or blood in sputum. 7.Unexplained blood in stool, painless hematuria, bleeding from external ear canal. 8.Irregular menstruation, heavy bleeding, irregular vaginal bleeding outside menstruation or after menopause. 9.Long-standing ulcers that do not heal. 10.Unexplained weight loss or hypothermia.