Swollen feet in liver cancer may indicate advanced stage of the disease, which may be caused by factors such as hypoproteinemia and portal hypertension. Liver cancer mostly refers to primary liver cancer, which is one of the common digestive system tumors and one of the malignant tumors with the highest mortality rate in China. There are numerous complications of liver cancer, and the complications of liver cancer in different stages are different. There may be the following reasons for swollen feet in liver cancer patients: 1. Hypoproteinemia: advanced stage of liver cancer is often combined with liver cirrhosis, liver function is seriously impaired, and the ability of synthesizing protein decreases, which will easily lead to hypoproteinemia, thus causing swollen feet; in addition, as liver cancer is a consumptive disease, it will also cause hypoproteinemia. 2. Portal hypertension: Liver cancer is often combined with cirrhosis, or the tumor compresses the portal vein, which can lead to the formation of portal hypertension, which is prone to serious ascites, and the venous pressure of the lower limbs will be increased, thus leading to swollen feet; 3. Cancer embolism/metastasis: patients with liver cancer can combine with portal vein and lower limb venous thrombus in the late stage, which leads to blood return obstacle; in addition, some patients can have distant metastasis, such as pelvic lymph node metastasis, etc., which can compress the vena cava or iliac blood vessels, leading to poor blood return to lower limbs, thus causing swollen feet. 4. There are many reasons for swollen feet, which may be caused by other primary diseases (abnormal heart function, abnormal renal function, double lower limb vascular disease, etc.), or normal physiological phenomena (such as standing for a long time, etc.). If any of the above abnormalities occurs or liver cancer is suspected, it is recommended to go to a regular hospital to evaluate the condition and follow the doctor’s instructions for treatment to avoid delaying the condition.