Blood creatinine remains high after dialysis for kidney disease is related to dialysis adequacy and so on. The adequacy of hemodialysis refers to the effective removal of uremic toxins and excess water (up to dry weight) from the patient’s body in a shorter period of time under the premise of a certain protein intake, so that uremic toxins are removed from the blood in the right amount and maintained at a certain level value in the inter-dialysis period. If the patient is poorly compliant and not able to dialyze regularly (3 dialysis sessions per week for 4 hours each), the blood creatinine and urea nitrogen clearance will be poor and the blood creatinine may remain high. If dialysis is sufficient, blood creatinine rises higher before the next dialysis, and it will take some time to slowly return to normal range. If the blood creatinine is still high after dialysis for kidney disease, it is recommended to communicate with the health care personnel of the hospital where dialysis is performed to clarify the cause and adjust the treatment plan in time.