Coughing and taking medicines are not effective because the correct cause of the cough has not been found. Cough can be caused by a variety of reasons, if the cough is caused by tuberculosis, cough variant asthma or gastroesophageal reflux disease, the use of commonly used cough medication is ineffective, and need to be targeted treatment, to avoid delaying the condition. 1. tuberculosis: if the patient is due to tuberculosis caused by the old cough, need to be treated by anti-tuberculosis drugs to relieve coughing symptoms, anti-tuberculosis drugs, including isoniazid, rifampicin, pyrazinamide and other drugs. 2. cough variant asthma: if the cough is caused by cough variant asthma, it can be treated by budesonide formoterol inhalation powder aerosol, salbutamol sulfate inhalation aerosol, so as to achieve anti-inflammatory, bronchial dilatation effect, and alleviate cough symptoms. 3. Gastroesophageal reflux disease (GERD): the reflux of gastric contents to stimulate the respiratory tract can also cause prolonged coughing, which can be relieved and improved by drugs such as sodium rabeprazole enteric-coated tablets, omeprazole magnesium enteric-coated tablets, domperidone tablets, and so on to alleviate the uncomfortable symptoms. The causes of coughing are many, if the treatment effect is not obvious after taking medication, you need to go to the hospital in time for examination, clear cause of the disease to give targeted treatment, to avoid misunderstanding, aggravate the symptoms and cause serious impact.