Bilateral mastoiditis can be cured with active and standardized treatment, but sometimes it will recur. It is recommended that patients seek timely medical treatment after the onset of the disease, to clarify the cause of the disease, and follow the doctor’s instructions to standardize the use of medication and treatment. The treatment of mastoiditis includes medication and surgery, and the medication includes antibiotics such as penicillin, ceftriaxone and other antibiotics. When antibiotic treatment does not improve, surgical treatment is needed to remove the diseased tissue and drain the pus, and the main surgical plan is mastoidectomy. Since the drugs are not absolutely safe and effective, it is recommended to use them according to the doctor’s instructions, and to consult the doctor in time if there are any adverse reactions, drug allergy is prohibited, and cephalosporins are prohibited from drinking alcohol during the use of the drugs. After standardized active treatment, the disease can often be cured, but because the disease is prone to recurrence, it is recommended that regular review to monitor the progress of the disease.