Staying up late may lead to sudden death, and staying up late causes sudden death often on top of having an organic disease basis. For underlying diseases, including structural changes in the heart, such as patients with congenital heart disease, and patients with primary cardiac diseases, such as dilated cardiomyopathy, hypertrophic cardiomyopathy, and restrictive cardiomyopathy. In addition, for severe electrolyte disorders, malignant arrhythmias are often induced by staying up late and other triggers, which can lead to the phenomenon of sudden death. For some people with normal heart structure and function, there can also be hereditary arrhythmias that often induce severe arrhythmic events leading to sudden death under triggering factors such as staying up late or exercising. Therefore, it is important to pay attention to therapeutic lifestyle improvement and regular work and rest to avoid malignant events.