Can an enlarged tongue be made smaller?

Not necessarily. The outcome of hypertrophy of the tongue is related to the etiology, such as.
hypertrophy of the tongue due to angioedema and lingual inflammation, the volume of the tongue can return to normal after the cause is removed.
Whereas in hypertrophy of the tongue caused by lymphoma of the tongue and rhabdomyosarcoma, the ability to reduce the size of the tongue is closely related to the type of pathology and the patient’s response to radiotherapy
Most hypertrophy of the tongue due to multiple myeloma and amyloidosis is irreversible.