Taking dehydrating agents, non-steroidal anti-inflammatory drugs, muscle relaxants, neurotrophic drugs, etc. can treat pyriformis syndrome, and can also be combined with massage and other physical therapy, and in severe cases, surgical treatment is needed. 1. Dehydration agent: representative of mannitol and other drugs, can effectively relieve local muscle edema, so as to symptomatically relieve the symptoms. 2. Non-steroidal anti-inflammatory drugs: commonly used, including Loxoprofen sodium, etc., to fight against localized aseptic inflammation of the pyriformis muscle, which is also one of the ways to relieve pain. 3. Muscle relaxants and neurotrophic drugs: when localized aseptic inflammation of the pyriformis muscle occurs, the muscle will be tense, the use of muscle relaxants such as epirubicin hydrochloride tablets can be symptomatically relieved, and neurotrophic drugs such as methylcobalamin can also alleviate the symptoms. The use of drugs need to be in accordance with the doctor’s instructions, and can be combined with massage and other physical therapy, serious patients need surgical treatment, it is recommended to consult a doctor in a timely manner, in accordance with the doctor’s instructions for treatment.