If the patient has nipple pain after ovulation, there is a possibility of pregnancy, but it does not mean that she is definitely pregnant. Generally, if the patient has intercourse at ovulation and becomes pregnant, it is at least one week before the patient’s blood chorionic gonadotropin, progesterone and estrogen levels rise significantly. It is possible that the rise in hormone levels after pregnancy may trigger a series of early pregnancy reactions, such as nausea, vomiting, breast tenderness as well as nipple pain and easy erection, etc. If the patient is ovulating followed by nipple pain, it is important to consider that it is not related to pregnancy in any way. The main reason is that after ovulation, progesterone will rise, and progesterone will act on the physiological enlargement of women’s breast, so it will lead to pain and discomfort in the nipples of patients.