Platelet high 400 may refer to the platelet count is greater than 400 × 10^9 / L, usually, is not particularly serious, the causes are divided into physiological, pathological two categories.
1. Physiological reasons: mainly due to the platelet count is affected by external factors, such as the afternoon or after exercise, emotional excitement, the platelet count will show a mild increase in the state, usually no special treatment is needed, it will recover by itself.
2. Pathological causes: If the platelet count is higher than 450×10^9/L, it is a pathological change, which may be caused by thrombocythemia, including primary and secondary.
Primary thrombocythemia is mostly due to myeloproliferative tumors, which can be treated with drugs such as hydroxyurea; secondary thrombocythemia can be seen in splenectomy, infections and other factors, which can be treated with targeted treatment, such as levofloxacin to fight infections and so on.
If the platelets are high 400×10^9/L, after excluding physiological reasons, you should consult a doctor in time, complete the relevant examinations, clarify the causative factors, and follow the doctor’s instructions to carry out targeted treatment.