High 25-hydroxyvitamin D is usually a result of accumulation of vitamin D in the body due to too much oral vitamin D. High vitamin D levels may cause adverse effects such as hypercalcemia and soft tissue calcification.
Vitamin D is a fat-soluble vitamin, a group of steroid derivatives with anti-rickets effect and similar structure. Its main function is to promote the absorption of calcium and phosphorus in the mucosal cells of the small intestine. It can increase blood calcium and phosphorus concentration, which is beneficial to new bone production and calcification. 25-hydroxyvitamin D is its mode of existence in the human body.
If patients accumulate it in the body as a result of taking too many oral vitamin D preparations, it can lead to VD hypercalcemia. This is mainly caused by hypercalcemia and the resulting renal impairment and soft tissue calcification. Patients should promptly stop taking vitamin D, if necessary with hormone therapy.
If the patient’s 25-hydroxyvitamin D level remains high and symptoms such as dizziness and nausea occur, the patient should go to the hospital immediately to avoid adverse consequences.