The cost of filler for lines is related to the filler material, with autologous fat filler costing around $5,000-$10,000 and hyaluronic acid filler costing around $4,000-$20,000. The method of filling, the amount of filling and the level of medical organization will affect the cost of the procedure. 1. Autologous fat filling is a surgical procedure that extracts and purifies fat from the waist, abdomen, and other areas with more fat, and injects it into the bilateral nasolabial fold depressions to be filled. The technology is more mature, but there is a short period of swelling and recovery, and the transplanted fat can be maintained in a long-term ideal state after it has been activated. 2. Hyaluronic acid filling is an injectable treatment, which can be done on an outpatient basis. The specific dosage of filler is related to the severity of the lines, and both the dosage of filler and the type of hyaluronic acid will affect the total cost of injection. Whether it is autologous fat or hyaluronic acid, both are invasive operations and there is a risk of embolism due to the rich blood supply in the face. If you need to fill in the frown lines, it is recommended that you go to a regular medical institution in order to avoid any adverse consequences.