Abdominal pain and discomfort, jaundice, emaciation, fatigue and gastrointestinal symptoms can appear in middle and late stages of pancreatic cancer. 1. Abdominal pain and discomfort: it mainly manifests as discomfort and pain in the upper abdomen, which is often hidden pain and dull pain. Progressive pain and low back pain may also occur, and the pain is obvious at night. 2. Jaundice: it is often manifested as yellowing of skin and sclera, yellowing of urine and clay-colored stool. Jaundice may be accompanied by itching of the skin, which is progressively aggravated. 3. Wasting and fatigue: weight loss, wasting and fatigue may occur. 4. digestive symptoms: often accompanied by loss of appetite, abdominal bloating, dyspepsia and other symptoms. Pancreatic cancer should be detected early, diagnosed early and treated early to improve the survival rate of patients.