There are many causes of persistent epigastric pain, which mainly include the following diseases in clinical practice: 1. Commonly, peptic ulcers, including gastric ulcers and duodenal ulcers, require further gastroscopy to clarify the diagnosis. Treatment with acid suppressants as well as antibiotics can obtain relief of symptoms or even cure. If persistent upper abdominal pain caused by peptic ulcer cannot be relieved repeatedly, it is necessary to be alert to the possibility of ulcer perforation.2. Biliary system diseases, including gallbladder stones, acute cholecystitis and acute cholangitis caused by bile duct stones, require further hepatobiliary ultrasound or even CT examination to clarify the diagnosis, and in serious cases, surgical treatment is required.3. See acute pancreatitis, caused by overeating or secondary biliary The abdominal CT and blood amylase are significantly elevated. Treatment is mainly fasting, acid control, gastrointestinal decompression, enzyme suppression and other symptomatic treatment, most patients can be cured through conservative treatment.