Herpes is caused by herpes virus, clinically, herpes simplex and herpes zoster are the most common. The main ingredient of Bactrim is mupirocin, a topical topical antibiotic that is more effective against bacterial infections caused by gram-positive cocci, such as impetigo, boils and folliculitis, etc. Bactrim has no definite therapeutic effect on herpes. Herpes mainly presents as clusters of small blisters that can be accompanied by pain, and some patients with herpes zoster can develop severe neuralgia. Treatment should be given as early as possible with anti-herpes virus drugs, which can be taken orally such as acyclovir and valacyclovir, and topically with acyclovir cream and penciclovir cream. For more serious herpes, especially herpes patients who have developed vesicles and ulcers are likely to have secondary bacterial infections, when Bactroban can be applied in combination.