Diabetic peripheral neuropathy is the first complication of diabetes and is often referred to as diabetic peripheral neuritis. Its typical symptoms are glove-like and garter-like pain, numbness and loss of deep sensation in the extremities, and muscle atrophy may occur. The pain often presents as a burning pain or a sharp, overwhelming pain. The pain and numbness are often worse at night than during the day, and patients often wake up from sleep with pain or numbness, or are unable to sleep through the night for years and years, seriously affecting their lives. To make matters worse, because the patient’s appearance seems to be unimpaired, this pain is often not understood by colleagues, friends or even family members, adding to the patient’s mental burden, and many of the patients who visit the clinic have depressive symptoms. In addition to the above direct symptoms, the most serious consequence of diabetic peripheral neuropathy is the diabetic foot, which, contrary to what many people, including doctors, think, is the first cause of diabetic foot, and nowadays one person worldwide has an amputation every 30 seconds due to diabetic foot. In addition, the deep sensory deficits in the lower extremities caused by diabetic peripheral neuropathy are often overlooked by patients and physicians alike. Many patients have varying degrees of lower limb tenderness and drifting, unstable walking, difficulty going down stairs than up, not knowing where their legs are without looking at their legs, and not daring to go down stairs at night, all of which are manifestations of impaired deep sensation, and in severe cases often fall and cause fractures, or even not being able to walk down to the ground at all, when the strength of the legs is often normal. Comprehensive above, diabetic patients who have the following symptoms, need to pay close attention, should go to the hospital for examination: 1, hands and feet pain, often like burning, or to the string of pain like electricity, not only pain during the day, but also pain at night, often more pain than during the day; often accompanied by a tingling sensation throughout the body; 2, hands and feet numbness, tightness, some feel numb fingertips, some feel very cold skin, summer also need to wear thick Socks, thick pants, some feel the extremities are wooden, like a stake, shoes are dropped do not know, or shoes with small stones can not feel; 3, the original is sweaty feet, but recently dry sweat, dry cracked peeling, even in the summer will be cracked, the sole of the foot calluses thicken, scraped with a blade soon thickened again. Toenail thickening and deformation, some appear long-lasting nail furuncle infection. 4, walking unstable, walking drifting, often inexplicably fall or stagger.