Whether adrenal nodule surgery is a major surgery needs to be judged according to the benign and malignant nature of the nodule and its size. 1. Adrenal nodules are divided into benign and malignant, benign nodules can be divided into functional nodules and non-functional nodules. Functional nodules, such as pheochromocytoma, will cause symptoms such as sweating, palpitations, constipation, etc., and will cause dramatic fluctuations in blood pressure during the operation, so it is a major surgery. General non-functional nodules can be treated by minimally invasive surgery such as laparoscopy, which is generally safer and not a major surgery. Malignant nodules require comprehensive pathology and imaging to determine the surgical plan, which is generally a major surgery. 2. The size of the nodule: there is no clear statement on how large the nodule needs surgery, but if the nodule is too large, the retroperitoneal space is more limited, the operation is difficult, and it is easy to damage the surrounding tissues, then it also belongs to the major surgery.