Blisters on the ankles, if the itching is pronounced, consider that it may be papular urticaria due to mosquito bites. Pemphigus urticaria is usually a pike-shaped rash, the surface can have blisters, itching is intense, mostly related to go to the outdoor activities with a lot of flowers and trees. Treatment can be given locally to the compound beclomethasone camphor cream topical, more rash can be given glucocorticoids oral, less rash oral antihistamines can be. If the blisters are caused by burns, it is recommended to use recombinant human epidermal growth factor gel with silver sulfadiazine or zinc sulfadiazine externally, pay attention to protect the wall of the blisters. Elderly patients with blisters also need to suspect whether the blisters are caused by autoimmune blister disease. At this time, we need to go to the regular hospital, the pathology examination and immunopathology examination to help clarify the diagnosis, the treatment is mainly to give glucocorticoid therapy.