There is no definitive conclusion as to how many generations neurofibromatosis is inherited. If both parents have neurofibromatosis or only one parent has neurofibromatosis, there is a chance that the offspring will be free of the disease. If the offspring do not have neurofibromatosis, the grandchildren will not have neurofibromatosis.
Neurofibroma is an autosomal dominant disease that develops when there is one dominant gene on an autosomal chromosome. Human germ cells are formed by meiosis, and when a fertilized egg is formed, nearly half of the genetic material comes from the father and the rest from the mother.
When both parents have neurofibromatosis, the offspring have a 75% or greater chance of carrying the dominant gene, and when one parent has neurofibromatosis, the offspring have a 50% or greater chance of carrying the dominant gene. In both cases, there is a chance that the offspring will not be inherited.
Therefore, there is no definite conclusion on how many generations of neurofibroma disease are inherited, and it is necessary to make specific judgments based on the genes of both parents and whether the offspring have the disease or not.