The effects of fasting on the liver mainly include fatty degeneration of liver cells and cholestasis. 1. Liver steatosis: Fasting will lead to insufficient intake of carbohydrates and insufficient supply of energy to the body, and the fat will enter the liver, which will be converted into sugar to supply energy to the body after being decomposed and metabolized by the liver. When too much fat enters the liver, it will be deposited in the liver cells, leading to fatty degeneration of the liver cells, which may lead to the occurrence of fatty liver over time, or even aggravate the degree of fatty liver. 2. Cholestasis: Bile is secreted by liver cells, concentrated and stored in the gallbladder, and excreted by the gallbladder into the intestines after eating to participate in digestion. Fasting will cause the gallbladder to be unable to excrete bile normally, resulting in bile stasis and retrograde storage of bile in the liver cells, which will persistently damage the liver cells, inducing liver inflammation and degeneration. Patients should follow medical advice regarding diet and activity and report any abnormalities to their healthcare provider immediately.