Midazolam is a commonly used drug during anesthesia, it will reduce the patient’s mental stress, let the patient sleep quietly, no consciousness during the operation, and its use mainly has the following points: 1, often used before the induction of general anesthesia, generally normal people are 5-10mg, that is, between 0.1-0.15mg/kg. This drug is used for general anesthesia, intraoperative patients will produce retrograde amnesia, forget all the unpleasant feelings during the operation, including the patient’s fear; 2, nerve block or intralesional anesthesia is used, the dosage is about 0.03-0.04mg/kg, injected in divided doses. Many patients will have a sense of fear during the operation, especially when doing orthopedic surgery, there are instrument knocking sounds, if you can’t make the patients well sedated and tranquilized, especially some children, they can’t cooperate with the operation during the operation, after using these drugs the patients will fall asleep quietly and be comfortable during the operation.