If you wake up in the morning and your mouth feels swollen, you may be suffering from a skin condition called angioedema. Angioedema is also a type of urticaria, which is a sudden swelling caused in areas with loose skin, for example, the mouth and lips are areas with loose skin, in addition, the vulva area is also prone to this swelling. If this happens, we can take oral antihistamines for treatment. Antihistamines are divided into first-generation antihistamines and second-generation antihistamines, and we can take second-generation antihistamines, and the combination of second-generation antihistamines and first-generation antihistamines is also possible. Second-generation antihistamines avoid the effect of drowsiness caused by first-generation antihistamines through the blood-brain barrier, so that second-generation antihistamines generally do not have the effect of drowsiness.