Closed mouth, also known as whiteheads, is one of the clinical manifestations of acne, which may be caused by exuberant secretion of sebaceous glands and over-keratinization of sebaceous gland openings of hair follicles, etc. The treatment of closed mouth can be carried out by using retinoic acid, benzoyl peroxide, salicylic acid and other medications under the guidance of a doctor. 1. Vitamin A drugs: the treatment of acne can be prescribed by the use of vitamin A drugs, such as adapalene gel, tazarotene gel, etc.; patients with rapid demand for therapeutic effects can also be prescribed oral vitamin A drugs, such as isotretinoin soft capsules, etc. The use of this drug must be strictly followed. The use of this drug must strictly follow the doctor’s instructions, to pay attention to the adverse effects of the drug, such as liver function abnormalities. Patients who are allergic to the drug are prohibited. 2. Benzoyl peroxide: the treatment of closed mouth can use benzoyl peroxide for treatment, this drug is a peroxide, after the slow release of new ecological oxygen and benzoic acid, can inhibit Propionibacterium acnes, and has dissolved acne and astringent effect. Patients who are allergic to this drug are prohibited. 3. Salicylic acid: Salicylic acid is usually used to treat closed mouth acne by chemical exfoliation. Salicylic acid has the effect of inhibiting the growth of P. acnes, anti-inflammatory or slight exfoliation. This medication should be used under medical supervision and is contraindicated in patients who are allergic to salicylic acid. In addition to the use of topical ointment treatment, acne with whiteheads and pimples patients can also use physical therapy under the guidance of a doctor, such as laser therapy, red and blue light irradiation treatment. It is recommended that patients standardize the use of medication under the guidance of the doctor, and at the same time pay attention to avoid eating spicy and stimulating food.