Due to individual differences, high blood sugar does not exist in the best efficacy of the drug, there are many kinds of hypoglycemic drugs, patients should be based on the specific situation, under the guidance of the doctor to choose the appropriate drugs for control. 1. Acarbose: It is one of the first-line therapeutic drugs for diabetes mellitus, mainly used for the treatment of type 2 diabetes mellitus with high postprandial blood glucose. 2. Metformin: It is one of the first-line drugs for the treatment of type 2 diabetes, with obvious glucose-lowering effect. Because of its weight-loss effect, it is more suitable for overweight or obese type 2 diabetes patients, and it can also be used for type 1 diabetes patients with big fluctuation of blood glucose after the application of insulin. 3. Pioglitazone: It is a thiazolidinedione hypoglycemic drug, mainly applicable to the treatment of type 2 diabetic patients whose blood sugar cannot be controlled by diet and exercise alone. Patients with high blood sugar should go to the hospital as soon as possible, choose the appropriate drugs for treatment under the guidance of the doctor, and follow the doctor’s instructions during the treatment, not to change the dosage on their own.