Intracranial infection is a condition frequently encountered in neurosurgery clinics, mostly caused by craniotomy, ventricular drainage, lumbar pool drainage, ventriculoperitoneal shunt and other invasive surgical operations, resulting in bacteria or viruses taking advantage of the opportunity to enter the cranium, thus causing intracranial infection. In the early stage, most patients present with fever, headache, vomiting, impaired consciousness, neck straightening, etc. If treatment is not taken in time, the condition will further deteriorate, making treatment more difficult and even life-threatening. How is the differential diagnosis of intracranial infection made? Differential diagnosis of intracranial infection cerebrospinal fluid examination The diagnosis of intracranial infection requires not only a comprehensive physical examination of the patient, but also a lumbar puncture to retrieve cerebrospinal fluid for examination to clarify the specific pathogenic bacteria in the cerebrospinal fluid. In general, the leukocyte WBC in cerebrospinal fluid examination is >0.01X109/L, with an increase in polymorphonuclear cells. In addition, cerebrospinal fluid bacterial culture is positive. It has been found by clinical practice that false negative cerebrospinal fluid bacterial cultures are more common, so a single cerebrospinal fluid test result that is negative may be retained several times for cerebrospinal fluid culture. Treatment of intracranial infection: Intracranial infection is divided into light and heavy. For patients with severe infection, the anti-infection treatment given by local hospitals is often not as effective as desired because of the blood-brain barrier, and patients are advised to go to the cerebrospinal fluid department of regular hospitals for scientific treatment at an early stage. The cerebrospinal fluid specialty technology can effectively solve all kinds of hydrocephalus and all kinds of intracranial infections, which is a great blessing for the majority of patients.