Liver and gallbladder stones include gallbladder stones and intrahepatic gallstones. Among them, gallbladder stones are usually not life-threatening to patients; a large number of intrahepatic gallstones may affect patients’ lives if they develop serious complications or become cancerous. Hepatobiliary stones include gallbladder stones and intrahepatic bile duct stones, which are mainly identified by ultrasound examination, but both have no specific symptoms in the early stage. Gallbladder stones may present with epigastric pain and pressure pain in the biliary area during an attack, and usually have a good prognosis after symptomatic treatment. Intrahepatic bile duct stones should be seen as early as possible after their appearance to avoid delaying the progression of the disease. In some patients, after repeated inflammation, it may lead to carcinoma, which may affect the patient’s life expectancy, depending on the degree of invasion and recurrence of cholangiocarcinoma. If discomfort in the biliary area, abdominal pain and jaundice occur, it is recommended to go to the hepatobiliary surgery department immediately for ultrasound and CT examination to confirm the cause of the disease and provide timely symptomatic treatment.